Jens Fogh Selected Research

alpha-Mannosidosis

11/2018	Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis.
10/2017	Long-term enzyme replacement therapy improves neurocognitive functioning and hippocampal synaptic plasticity in immune-tolerant alpha-mannosidosis mice.
11/2015	Chronic enzyme replacement therapy ameliorates neuropathology in alpha-mannosidosis mice.
6/2015	Alpha-mannosidosis: correlation between phenotype, genotype and mutant MAN2B1 subcellular localisation.
6/2013	Natural history of alpha mannosidosis a longitudinal study.
1/2010	Impaired lysosomal trimming of N-linked oligosaccharides leads to hyperglycosylation of native lysosomal proteins in mice with alpha-mannosidosis.
11/2008	Reversal of peripheral and central neural storage and ataxia after recombinant enzyme replacement therapy in alpha-mannosidosis mice.
9/2004	Efficacy of enzyme replacement therapy in alpha-mannosidosis mice: a preclinical animal study.

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Jens Fogh Research Topics

Disease

10	Lysosomal Storage Diseases (Lysosomal Storage Disease) 11/2015 - 05/2005
8	alpha-Mannosidosis 11/2018 - 09/2004
8	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 06/2012 - 05/2005
3	Neuronal Ceroid-Lipofuscinoses (Neuronal Ceroid Lipofuscinosis) 01/2022 - 01/2020
3	Demyelinating Diseases (Demyelinating Disease) 09/2015 - 05/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 10/2021
2	Gliosis 10/2021 - 09/2015
2	Nervous System Diseases (Neurological Disorders) 11/2015 - 04/2009
2	Body Weight (Weight, Body) 05/2005 - 09/2004
1	Parkinson Disease (Parkinson's Disease) 01/2022
1	Synucleinopathies 01/2022
1	Weight Loss (Weight Reduction) 10/2021
1	Blindness (Hysterical Blindness) 01/2020
1	Globoid Cell Leukodystrophy (Krabbe Disease) 09/2015
1	Neuroinflammatory Diseases 09/2015
1	Central Nervous System Diseases (CNS Diseases) 07/2011
1	Mannosidase Deficiency Diseases (Mannosidosis) 01/2011
1	Ataxia (Dyssynergia) 11/2008
1	Sphingolipidoses (Sphingolipidosis) 04/2008
1	Anaphylaxis (Anaphylactic Shock) 09/2007
1	Neurologic Manifestations (Neurological Manifestations) 05/2005
1	Inborn Genetic Diseases (Disease, Hereditary) 09/2003
1	Acute Intermittent Porphyria (Porphyria, Acute) 09/2003

Drug/Important Bio-Agent (IBA)

9	EnzymesIBA 01/2022 - 09/2003
8	alpha-Mannosidase (LAMAN)IBA 11/2018 - 09/2004
7	Cerebroside-Sulfatase (Arylsulfatase A)IBA 06/2012 - 05/2005
5	Mannose (D-Mannose)IBA 01/2022 - 09/2004
4	Cathepsin BIBA 01/2022 - 01/2010
4	OligosaccharidesIBA 11/2015 - 09/2004
4	Sulfoglycosphingolipids (Sulfatides)IBA 07/2011 - 05/2005
3	SaposinsIBA 01/2022 - 01/2020
3	Lysergic Acid Diethylamide (LSD)IBA 01/2020 - 04/2009
3	AcidsIBA 10/2017 - 09/2004
3	HydrolasesIBA 11/2015 - 04/2009
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022 - 01/2020
2	Lysosomal-Associated Membrane Protein 1IBA 01/2022 - 01/2020
2	Cathepsin DIBA 01/2022 - 01/2020
2	Phosphates (Orthophosphate)IBA 01/2022 - 01/2020
2	Protein AggregatesIBA 10/2021 - 01/2020
2	Proteins (Proteins, Gene)FDA Link 10/2021 - 01/2020
2	Cathepsin LIBA 10/2021 - 01/2020
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	coomassie Brilliant BlueIBA 01/2022
1	Glucosylceramidase (Glucocerebrosidase)IBA 01/2022
1	Amino Acids FDA Link 01/2022
1	Prion ProteinsIBA 01/2022
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 01/2022
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 01/2022
1	IGF Type 2 Receptor (Insulin-Like-Growth-Factor II Receptor)IBA 01/2022
1	Polymethyl Methacrylate (Sol)IBA 01/2022
1	SynucleinsIBA 01/2022
1	Peptide Hydrolases (Proteases)FDA Link 10/2021
1	LipofuscinIBA 01/2020
1	LDL Lipoproteins (beta Lipoproteins)IBA 01/2020
1	Adenosine Triphosphate (ATP)IBA 01/2020
1	BuffersIBA 01/2020
1	Tripeptidyl-Peptidase 1IBA 01/2020
1	LDL Receptors (LDL Receptor)IBA 01/2020
1	Lysosomal-Associated Membrane Protein 2IBA 01/2020
1	CeroidIBA 01/2020
1	oxidized low density lipoproteinIBA 01/2020
1	Low Density Lipoprotein Receptor-Related Protein-1 (LDL-Receptor Related Protein)IBA 01/2020
1	Glial Fibrillary Acidic ProteinIBA 01/2020
1	procathepsin DIBA 01/2020
1	Psychosine (Galactosylsphingosine)IBA 09/2015
1	GalactosylceramidaseIBA 09/2015
1	GangliosidesIBA 01/2011
1	cholesterol-binding proteinIBA 01/2011
1	CholesterolIBA 01/2011
1	Glycoproteins (Glycoprotein)IBA 01/2010
1	Man(3)GlcNAc(2)IBA 01/2010
1	Polysaccharides (Glycans)IBA 01/2010
1	lysosomal proteinsIBA 01/2010
1	AntibodiesIBA 04/2008
1	SphingolipidsIBA 05/2005
1	Heme (Haem)IBA 09/2003
1	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 09/2003

Therapy/Procedure

11	Enzyme Replacement Therapy 01/2022 - 09/2004
4	Intravenous Injections 06/2012 - 09/2007
1	Injections 05/2005
1	Intravenous Administration 09/2004